There is currently no treatment that can completely cure Man on Fire syndrome, but there are things that can help with the pain. Patients with CIP have a completely dysfunctional Nav1.7 channel, which accounts for part of their disease, but CIP is also caused because of increased production of endorphins in the brain. A person with CIP can be harmed and not know it, and they may not be able to have the proper response to pain or may not be able to describe their pain at all. Patients who suffer from CIP can’t feel pain at all, which may sound like a great thing on the surface, but pain serves to tell humans when they are in danger.
The other extreme concerning chronic pain is Congenital Insensitivity to Pain or CIP. The defect of these channels is not the same in all patients, which can cause some to have more or more intense pain than others.
The Nav1.7 channels can have a defect that allows many sodium ions into the nerves, which in turn increases the sensitivity in the nerves and can be responsible for the intense pain those with Man on Fire syndrome experience. One of these specific channel proteins in the C-fibers in the Nav1.7, which is present in great numbers in the C-fibers. C-fiber nerves that line the spinal cord have channel proteins in them, which allow messages to be transmitted within and through the nerves. Why Does it Happen?Īs mentioned above, erythromelalgia is inherited, but the reason for the pain goes deeper and deals with specific nerves. Many people who suffer from Man on Fire syndrome explain that putting on socks or shoes is something that can also trigger an attack. These instances vary in frequency from patient to patient and can be attributed to heat, pressure, exertion, or stress, even in the smallest degrees. However, the pain usually isn’t quick or dull but is sharp and slow. This causes severe, burning pain, usually either a radiating or shooting type, in the fiber sensory nerves that are found along the spinal cord. Any plan switch after redemption of this offer will result in forfeiture of the discount pricing.The vessels can then become swollen when the blood flow to the tissues increases and inflamed.
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